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Siena – A single mutation in the receptor binding site of the spike protein was enough to make JN.1 inaccessible to most antibodies acquired through vaccination or infection. A team of researchers from Italy has analyzed the latest immune evasion of SARS-CoV-2 in Science Immunology (2024; DOI: 10.1126/sciimmunol.adp9279) down to the molecular basis. Antibodies achieve the best neutralizing effect when they bind to the…