Antisense therapy against alpha-synuclein stops Parkinson’s in mice

Antisense therapy against alpha-synuclein stops Parkinson’s in mice

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medicine

Tuesday, August 20, 2024

Tokyo – Japanese researchers have stopped the spread of a synucleinopathy, which in humans includes Parkinson’s disease, in mice by injecting antisense oligonucleotides into the brain. The results presented in Acta Neuropathologica Communications (2024; DOI: 10.1186/s40478-024-01766-3) confirm the assumption that the disease spreads in the brain like a prion. In Parkinson’s disease, however…

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